Fermentation thiab tshuaj ua lag luam feem ntau ntsib kev tsis meej pem thaum xaiv cov khoom siv los tiv thaiv -corrosion cua sov. Qhov muag tsis pom kev ntawm tus nqi pib qis qis ua rau muaj kev hloov pauv tsis tu ncua thiab tsis tau npaj kaw, thaum kev nrhiav ntau dhau ntawm siab - kawg titanium heaters ua rau tsis muaj peev txheej pov tseg. Plaub lub ntsiab tiv thaiv-cov khoom siv cua sov, uas yog 316L stainless hlau raj, ntshiab titanium raj, quartz raj thiab PFA coated heaters, muaj qhov tshwj xeeb adaptability rau kev tshaj tawm nrog cov kua qaub sib txawv, cov ntsiab lus chloride, fluoride ion thiab kub. Daim ntawv no tsim cov qauv kev xaiv nyiaj txiag ntau raws li qhov nruab nrab corrosivity grading, suav nrog kev nqis peev hauv thawj zaug, kev siv hluav taws xob, nqi tu thiab kev kaw qhov poob, los muab lub hom phiaj kev txiav txim siab- ua lub hauv paus rau kev yuav khoom.
Ua ntej, qhov nruab nrab ua haujlwm tau muab faib ua plaub qib corrosivity raws li cov qauv kev faib tawm tseem ceeb. Qib ib yog hais txog qhov nruab nrab corrosion me me nrog cov organic acid tsawg, tsis muaj ntsev thiab chav tsev - kub CIP tu, xws li diluted saccharification kua thiab qis -concentration poov xab kab lis kev cai nruab nrab. Nyob rau hauv cov xwm txheej no, 316L stainless hlau cua sov tubes qhia txog kev pom kev lag luam zoo. Nws tus nqi yuav khoom yog qhov qis tshaj ntawm plaub hom, thiab kev tu txhua hli passivation tuaj yeem lav kev ua haujlwm ruaj khov rau ntau tshaj peb xyoos. Titanium thiab PFA cov cua sov coj rov ua dua los tiv thaiv- kev ua haujlwm corrosion thiab cov nqi ntxiv, thaum cov quartz raj raug tshem tawm vim tsis muaj zog thiab tsis zoo rau kev hloov pauv cua sov.
Qib ob yog nruab nrab corrosive nruab nrab uas muaj lactic acid, acetic acid thiab qis -concentration chloride ions, nrog alternating kub acid thiab kub alkali ntxuav hauv qab 60 degree, uas npog feem ntau cov zaub mov fermentation ntau lawm kab. Nyob rau theem no, tus nqi sib txawv ntawm 316L thiab PFA cov cua sov ua kom pom tseeb. Stainless hlau raj xav tau kev txhim kho peb lub hlis twg qhov tsis txaus ntseeg thiab nquag descaling kom ncua pitting corrosion, thiab cov kev siv nyiaj ntau ntxiv nce txhua xyoo. PFA heaters zam hlau corrosion, tab sis thermal kuj ntawm fluoroplastic txheej ua rau kom ntev - lub sij hawm siv zog. Ntshiab titanium raj muaj tus nqi pib dua me ntsis, tab sis tus kheej - kho cov yeeb yaj kiab tsis tu ncua txiav tu ntau zaus ntau dua li ib nrab, qhia tau zoo dua tsib- xyoo puv - kev lag luam kev lag luam.
Qib peb yog siab -corrosion nruab nrab nrog cov tshuaj chloride siab thiab siab organic acid concentration, feem ntau ntawm cov amino acid thiab cov tshuaj sterile fermentation tanks . 316L stainless hlau tsis tuaj yeem ua haujlwm ruaj khov rau ntau tshaj ib xyoos hauv ib puag ncig no; pitting corrosion nkag mus rau hauv lub raj phab ntsa sai, ua rau nquag nruab nrab to thiab batch seem poob. PFA heaters fim zais qhov phom sij ntawm txheej txheej blistering nyob rau hauv ntev - lub sij hawm mus tas li cua sov, thiab lub zos pinholes ua rau substrate xeb. Tsuas yog TA2 ntshiab titanium cua sov raj hloov mus rau qhov kev ua haujlwm no. Txawm hais tias ib qho - lub sij hawm nqis peev yog siab, xoom hlau ion nag lossis daus ua tau raws li GMP cov cai, thiab kev pabcuam lub neej ncav cuag 4-5 xyoo yam tsis muaj kev hloov kho ntau zaus, txo qis kev poob qis.
Qib plaub stands rau tshwj xeeb corrosive ua hauj lwm tej yam kev mob, nrog rau muaj zog acid uas muaj ib tug fluoride, siab - kub concentrated acid thiab kuaj me me -batch reagent cua sov. Titanium tubes tsis muaj fluoride- muaj nruab nrab vim fluoride dissolves titanium dioxide passive zaj duab xis. Quartz cua sov raj ua qhov kev xaiv zoo tshaj plaws rau luv luv -lub sij hawm sib quas ntus muaj zog acid cua sov vim tsis muaj acid tsis kam thiab xoom impurity dissolution. PFA cov cua sov tsuas yog siv tau yog tias qhov nruab nrab kub tswj tau qis dua 110℃yam tsis muaj cov khoom siv scouring. Siab -kub kub alkali ua hauj lwm tej yam kev mob tsis suav nrog quartz raj, raws li alkali kua etches quartz iav nto thiab ua rau lub raj rupture txaus ntshai.
Tag nrho - qauv kev lag luam hauv lub neej yuav siv sijhawm tsib xyoos raws li lub voj voog kev ntsuas thiab ntsuas plaub tus nqi modules. Tus nqi pib yuav yog tsawg dua 30% ntawm tag nrho cov kev siv nyiaj rau siab -corrosion ntau lawm kab, thaum qhov kev poob qis los ntawm cov khoom siv tsis ua hauj lwm tam sim ntawd yog qhov loj tshaj plaws. Cov tuam txhab lag luam yuav tsum tsis txhob tsuas yog sib piv cov nqi hais lus ib leeg thiab muab cov qib nruab nrab corrosivity, lub sijhawm ua haujlwm tsis tu ncua thiab cov txheej txheem ntxuav kom phim cov khoom siv cua sov.
Hauv cov ntsiab lus, qhov nruab nrab corrosivity grading yog lub hauv paus tseem ceeb rau kev xaiv ntawm kev xaiv los tiv thaiv -corrosion heaters. 316L stainless hlau haum me ntsis corrosion tsis sib xws ntau lawm, PFA suits nruab nrab corrosion qis- kub ua hauj lwm tej yam kev mob, ntshiab titanium ntais ntawv siab -corrosion nruam sterile sterile ferrment luv -lub sij hawm cua sov. Kev siv cov qauv kev lag luam hierarchical no tuaj yeem sib npaug cov khoom siv tswv yim, kev tswj xyuas kev ua haujlwm thiab kev tsim khoom ruaj khov, ua kom zoo tshaj plaws rov qab los ntawm kev nqis peev ntawm cov tshuab cua sov.
